Technology & Engineering

Chlorhexidine for sustained release in dental applications

Owing to its effective antimicrobial properties, Chlorhexidine (CHX) in the form of chlorhexidine diacetate is used in oral healthcare consumer products, such as mouthwashes, to improve dental hygiene. However, as a mouthwash CHX’s effectiveness is limited because it is easily washed away before it reaches the site of bacterial infection. CHX has been incorporated into gels, e.g. Corsodyl, so that it can be applied where needed and be effective for longer. In these gels, though, liquid chlorhexidine digluconate is used as the active agent, leading to relatively low concentrations of CHX released over limited time periods as the liquid CHX leaks out of the gel.

The technology is a new chlorhexidine polymorph with controlled size and unique spherical biomimetic morphology which produces a controlled drug release. It is based on defined chemistry and the crystals form a porous network creating a reservoir of high Chlorhexidine content and a controllable slow-release effect.

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